阳泰,男,理学博士,教授,硕士生导师,四川省学术和技术带头人后备人选。兼任四川省医学会转化医学专业委员会委员,四川省、成都市科技青年联合会理事,四川省预防医学会病原微生物与生物安全管理分会委员等。为Acta Pharmaceutica Sinica B, International Journal of Immunopathology and Pharmacology以及Cancer Chemotherapy and Pharmacology等药理学国际期刊审稿人。主要从事药物以及候选分子新靶标以及效应机制研究。承担国家自然科学基金项目、中央引导地方科技发展资金面上项目以及四川省科技厅创新人才等项目。以第1作者和通讯作者在British Journal of Pharmacology、European Journal of Pharmacology以及Asian Journal of Pharmaceutical Sciences等专业药理学杂志发表论著21篇,其中SCI收录论文18篇,JCR学科领域前10%论文4篇,高被引论文1篇。申请国家发明专利6项,已获授权3 项。
一、研究项目(近5年):
纵向项目
1. 基于膜脂筏探究PPARα激动剂抑制ERK活性协同蛋白酶体抑制剂杀伤多发性骨髓瘤细胞效应及机制,中央引导地方科技发展资金自由探索类基础研究项目,2022ZYD0093,20220901-20230831,40万元。
2. ATF4调控S1(2)P/SREBPs在蛋白酶体抑制剂诱导多发性骨髓瘤细胞脂质代谢重编程中的效应机制研究,四川省科技厅科技创新人才项目,2021JDRC0037,20210401-20240331,20万元。
3. 和厚朴酚磷酸酯前药设计及其临床适应症药效学筛选研究,成都市科技局技术创新研发项目,2018-YF05-00454-SN,2019.01-2020.01,10万元。
横向项目
1. 抗腹膜纤维化研究项目,成都青山利康药业股份有限公司,2024年,13万元。
2. 新型腹膜透析液研发项目,成都青山利康药业股份有限公司,2024年,13万元。
3. 新型Tubulin以及RIPK1抑制剂抗光化性角化病以及炎症性肠病研究,2021年,15万元。
4. 粪菌芽孢纯化治疗技术以及资源开发平台的建立,2021年,20万元。
5. 新靶标、新机制药物活性评价以及成药性研究,2020年,15万元。
二、论文发表(近5年):
1. Xiaojun Hu#, Renhan Dong#, Sheng Huang#, Yisheng Zeng, Wei Zhan, Xiaofang Gao, Dong Tian, Jian Peng, Jiewei Xu, Ting Wang, Yaying Zhang, Xiaohui Wang, Xiaoxia Zhang, Jin Liu*, Bing Guang*, Tai Yang*. CDBN-YGXZ, a Novel Small-Molecule Drug, Shows Efficacy against Clostridioides difficile Infection and Recurrence in Mouse and Hamster Infection Models. Antimicrob Agents Chemother. 2023, 67(5):e0170422(JCR一区,影响因子4.9).
2. YishengZeng#,Jian Peng#,XiaofangGao#, Dong Tian#, Wei Zhan,Jin Liu, Xiaojun Hu, Sheng Huang, Shuting Tian, Lan Qiu, Ailing Liang, Fuyu Wang, Renhan Dong*, Bing Guang*,Tai Yang*.A novel gut-restricted RIPK1 inhibitor, SZ-15, ameliorates DSS-induced ulcerative colitis. European Journal of Pharmacology. 2022, 937: 175381通讯作者(JCR一区,影响因子5.0).
3. Jian Peng#,YishengZeng#,Xiaojun Hu#, Sheng Huang,XiaofangGao, Dong Tian, Shuting Tian, Lan Qiu, Jin Liu, Renhan Dong, Wei Zhan, Chuanjun Qin, Bing Guang*,Tai Yang*. KC-180-2 exerts anti-SCLC effects via dual inhibition of tubulin polymerization and Src signaling. ACS Omega. 2022, 7(36): 32164-32175通讯作者(JCR一区,影响因子4.2).
4. Gaojie Xu#, Sheng Huang#, Jian Peng#, Xiaofang Gao, Minhui Li, Sisi Yu, Zuofeng Liu, Pengfan Qie, Yu Wang, Siqi Yu, Siyuan Liu, Hu Wen, Lijuan Su, Ping Li, Bin Guang, Renhan Dong, Jin Liu*,Tai Yang*. Targeting lipid metabolism in multiple myeloma cells: rational development of a synergistic strategy with proteasome inhibitors. British Journal of Pharmacology. 2021, 178 (23): 4741-4757通讯作者(JCR一区Top期刊,学科领域前5%,影响因子9.473)
5. Zijing Ruan#, Chao Liu, Yuting Guo, Zhenqing He, Xinhe Huang, Xu Jia*,Tai Yang*. SARS‐CoV‐2 and SARS‐CoV: Virtual screening of potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12). J Med Virol. 2021, 93(1): 389-400通讯作者(JCR一区,学科领域前10%,影响因子20.693)
6. Chao Liu#, Xiaoxiao Zhu,Yiyao Lu, Xianqin Zhanga, Xu Jia*,Tai Yang*,. Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2. Journal of Pharmaceutical Analysis. 2021, 11(3): 272-277通讯作者(JCR一区,学科领域前5%,影响因子14.026,高被引论文)
7. Gaojie Xu#, Renghan Dong#, Jin Liu#, Li Zhao, Yan Zeng, Xiaofan, Xiao, Jinlin An, Sheng Huang, Yueling Zhong, Bing Guang*,Tai Yang*.Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats’ brain ischemia-reperfusion injury, Asian Journal of Pharmaceutical Sciences, 2019, 24(6):640-648通讯作者(JCR一区,学科领域前10%,影响因子9.273)
8. Yueling Zhong#, Gaojie Xu#, Sheng Huang, Li Zhao, Yan Zeng, Xiao-fan Xiao, Jing-lin An, Jin Liu*,Tai Yang*.Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity, European Journal of Pharmacology, 2019, 853(15):184-192通讯作者(JCR一区,影响因子5.195)