栾广信,男,理学博士,硕士生导师。四川省遗传学会理事,四川省生物信息学会理事,四川省医学会微生物与免疫青年委员会委员。主要从事临床细菌耐药机制研究、临床细菌噬菌体分离纯化分析及难治性细菌感染的噬菌体治疗;并开展细菌与噬菌体的“攻防互作”机制研究。主持国家自然基金青年项目一项,主持国家科技基础资源调查专项子任务一项;发表SCI学术论文16篇,其中第一作者或通讯作者发表SCI学术论文9篇,授权国家发明专利1项。
一、荣誉称号及奖励:
无
二、研究项目(近5年):
(1) 国家科技部, 省部级, SQ2022FY010025, 我国感染相关捕食性微生物资源本底调查, 2022-10 至2025-09, 在研, 参与
(2) 成都医学院, 非编码RNA实验室专项, FB19-06, 基因编辑改变鲍曼不动杆菌噬菌体宿主谱的研究,2019-01 至 2022-12, 结题, 主持
近年发表的论文
1.Xianggui Yang#,Jun Zeng#,Dan Wang#,Qin Zhou#,Xuejing Yu,Zhenguo Wang,Tingting Bai,Guangxin Luan*,Ying Xu*; NagZ modulates the virulence ofE. cloacaeby acting through the gene of unknown function, ECL_03795.Virulence. 2024,15(1):2367652. DOI: 10.1080/21505594.2024.2367652.(共同通讯)
2. Penggang He#, Feng Cao#, Qianyu Qu, Huaixin Geng, Xin Yang, Tong Xu, Rui Wag, Xu Jia, Mao Lu*, Peibin Zeng*,Guangxin Luan*; Host range expansion of Acinetobacter phage vB_Ab4_Hep4 driven by a spontaneous tail tubular mutation.Frontiers in Cellular and Infection Microbiology.2024,14:1301089. DOI: 10.3389/fcimb.2024.1301089.(通讯作者)
3. Huaixin Geng#, Lingjie Song#, Xianggui Yang#, Siyu Xing, Rui Wang, Ying Xu*, Xu Jia*,Guangxin Luan*; Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure,Microbiology Spectrum, 2023, 11(3). DOI: 10.1128/spectrum.04384-22. (通讯作者)
4. Qianyu Qu#, Tao Chen#, Penggang He, Huaixin Geng, Peibin Zeng*,Guangxin Luan*;Isolation and characterization of a novel lytic bacteriophage vB_Efm_LG62 infecting Enterococcus faecium,Virus Genes,2023,59(5):763-774. DOI:10.1007/s11262-023-02016-9.(通讯作者)
5. Xiaokui Zhu#, Changwu Yue#, Huaixin Geng#, Lingjie Song, Huiming Yuan, Xianqin Zhang, Chuanyu Sun,Guangxin Luan*, Xu Jia*;Coexistence of tet(A) and blaKPC-2 in the ST11 hypervirulent tigecycline- and carbapenem-resistantKlebsiella pneumoniaeisolated from a blood sample,European Journal of Clinical Microbiology & Infectious Diseases, 2022, 42: 23-31.DOI: 10.1007/s10096-022-04512-6(共同通讯)
6. Song Lingjie#, Yang Xianggui#, Huang Jinwei, Zhu Xiaokui, Han Guohui, Wan Yan, Xu Ying,Guangxin Luan*, Jia Xu*.Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.Frontiers in Microbiology,2021,12:739319. DOI:10.3389/fmicb.2021.739319(共同通讯)
专利
(1) 宋灵洁; 栾广信; 贾旭 ; 一株针对高毒力肺炎克雷伯氏菌的新噬菌体及其应用, 2020-10-20, 中国,CN202011128064.1 (专利)