董勇，副教授，硕士生导师。2018年毕业于中国科学院广州生物医药与健康研究院，2018-2022年在中国医学科学院北京协和医学院/输血研究所开展博士后研究工作，2022年4月入职成都医学院/基础医学院。近年来主持博士后基金、国家自然科学基金等项目2项，以第一作者或共同第一作者在Nature immunology、Redox Biology、Cell proliferation、Cells、Journal of leukocyte biology 等杂志上发表论文六篇。现主要研究方向为造血发育及白血病的分子调控机制。

一、研究项目

1.构建人多能干细胞向功能性T细胞分化的3D培养体系, 中国博士后科学基金面上项目，负责人，结题。

2.转录因子ELK1 在人类中性粒细胞谱系决定过程中的分子机制研究；国家自然科学基金青年项目，负责人，在研。

二、主要研究成果

1. Dong, Y.Zhang, Y. Zhang, Y. Pan, X. Bai, J. Chen, Y. Zhou, Y. Zhou, Q. Lai,Z . Zhang, Y. Chen,Q. Hu, S. Ma,F. Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model.Redox Biology.2022 Aug;54:102392.

2. Chen, Y.Dong, Y.Lu, X. Li, W. Zhang, Y. Mao, B. Pan, X. Li, X. Zhou, Y. An, Q. Xie, F. Wang, S. Xue, Y. Cai, X. Lai, M. Zhou, Q. Yan, Y. Fu, R. Wang, H. Nakahata, T. An, X. Shi, L. Zhang, Y. Ma, F.., Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts.J Mol Cell Biol.2022 May 20;14(2):mjac001.

3.Dong, Y.Bai, J. Zhang, Y. Zhou, Y. Pan, X. Li, X. Zhou,Q. Chen,Y. Lai, M. Mao,B. Bian,G. Feng, J. Xie,F. Chen,B. Nakahata,T. Zhang,Y. Ma,F. Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals.J Leukoc Biol.2020 Dec;108(6):1711-1725.

4.Dong, Y.,K. Wang, Q. Weng, T. Wang, P. Zhou, X. Liu, Y. Geng, L. Liu, H. Wu, J. Wang, and J. Du. NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting.Cell Prolif.2020 Sep;53(9):e12885.

5.Dong. Y. ,C. Xia, Q. Weng, T. Wang, F. Hu, K. Wang, X. Liu, Y. Geng, L. Liu, H. Wu, and J. Du. Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition.Cells.2019 Aug 22;8(9):951.

6.. Zhang M#,Dong Y#,Hu F#, Yang D, Zhao Q, Lv C, Wang Y, Xia C, Weng Q, Liu X, Li C, Zhou P, Wang T, Guan Y, Guo R, Liu L, Geng Y, Wu H, Du J, Hu Z, Xu S, Chen J, He A, Liu B, Wang D, Yang YG, Wang J. Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.Nat Immunol.2018 Mar;19(3):279-290.

7. Yang D#, Zhang X#,Dong Y#,Liu X, Wang T, Wang X, Geng Y, Fang S, Zheng Y, Chen X, Chen J, Pan G, Wang J. Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.Cell Cycle.2015;14(4):612-20. doi: 10.4161/15384101.2014.992191. PMID:25590986