黄四洲,教授,硕士生导师、四川省学术与技术带头人后备人选、四川省解剖学会理事、省科技青年联合会理事,中国细胞生物学会、中国解剖学会会员。近年来主持国家自然科学基金3项、省部级项目2项、局厅级等项目6项,发表论文23篇,其中在Plos Biol、J cell biol等杂志SCI论文15篇。2015.01-2017.04获得英国皇家科学院牛顿国际奖学金(Royal Society Newton International Fellowships)K.C Wong Fellowship在英国华威大学及爱丁堡大学从事两年余博士后研究。现主要以斑马鱼为模式动物研究肝脏发育再生及肝癌发生的分子调控机理。
一、荣誉称号及奖励:
重庆市优秀博士论文、2012年西南大学优秀论文奖、2015年成都医学院科技论文一等奖、先进科技工作者、2018年成都一许愿优秀教师(科研类)。
二、研究项目(近5年):
1.RA下游因子Aplnra/b在斑马鱼器官左右不对称模式建成中的时空调控作用及机制研究,国家自然科学基金面上项目,编号31470080,2015.01-2016.12,负责人,结题。
2.视黄酸下游因子Cxcr4a在心脏前体细胞发育及形态建成中的作用及机制研究,国家自然科学基金应急项目,编号31741091, 2018.01-2018.12,负责人,结题。
3.Identifying protein partners that mediate dorsal localiztion of sqiunt RNA in zebrafish embryos.英国皇家学会联合项目,编号NF140476,2015.2-2017.01,负责人,结题。
4.心脏发育早期RA信号紊乱致先心病表型发生机制研究,四川省科技厅基础运用项目,编号2013JY0066,2013.01-2015.12,负责人,结题。
5.细胞因子Geminin在心脏发育中作用机制的研究,四川省教育厅自然科学重点项目,编号18Z021, 2018.01-2020.12,负责人,在研。
6.细胞周期因子MCM5在红细胞发生中的作用研究 四川省发育与再生重点实验室项目,校级,编号19SYS005,2019.01-2021.12,负责人,在研
7.肝脏及心脏早期前体细胞发生与左右模式建成,校基金(自然科学团队项目),编号CYTD1901,2020.01-2022.12,负责人,在研。
三、发表论文
1.Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. Zhu C, Guo Z, Zhang Y, Liu M, Chen B, Cao K, Wu Y, Yang M, Yin W, Zhao H, Tai H, Ou Y, Yu X, Liu C, Li S, Su B, Feng Y,Huang S*.Int J Biol Sci.2019 11;15(6):1225-1239.
2.Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking.Liu J, Zhu C, Ning G, Yang L, Cao Y,Huang S*,Wang Q*.PLoS Biol. 2019, 17(8):e3000203. doi: 10.1371/journal.pbio.3000203.
3.BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development.Huang S#,Wang Y#, Luo L, Li X, Jin X, Li S, Yu X, Yang M, Guo Z.Front Cell Neurosci. 2019 Dec 3;13:523. doi: 10.3389/fncel.
4.Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling. Huang W, Zhang Y, Cao K, Luo L*,Huang S*.Biomed Res Int.2018 Jun 7;2018:6543196. doi: 10.1155/2018/6543196. eCollection
5.PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development.Huang S#,Li Q, Alberts I, Li X.J Cell Biochem. 2016 Mar;117(3):566-73. doi: 10.1002/jcb.25304.
6.Translational co-regulation of a ligand and inhibitor by a conserved RNA element.
Zaucker A, Nagorska A, Kumari P, Hecker N, Wang Y,Huang S,Cooper L, Sivashanmugam L, VijayKumar S, Brosens J, Gorodkin J, Sampath K. Nucleic Acids Res. 2018 Jan 9;46(1):104-119. doi: 10.1093/nar/gkx938.
7.p53 Plays a Key Role in the Apoptosis of Human Ovarian Cancer Cells Induced by Adenovirus-Mediated CRM197. Dai L, Pan Q, Peng Y,Huang S, Liu J, Chen T, Wang X, Chen D, Wang J, Zhu Y, Wang H, Liu Y, Ou Y, Yu X, Cao K.Hum Gene Ther. 2018 Aug;29(8):916-926. doi: 10.1089/hum.
8.Adenovirus-Mediated CRM197 Sensitizes Human Glioma Cells to Gemcitabine by the Mitochondrial Pathway. Dai LX, Yang J, Liu JM,Huang S,Wang BN, Li H, Yang J, Zhao ZY, Cao K, Li MY.Cancer Biother Radiopharm.2019 Apr;34(3):171-180. doi: 10.1089/cbr.2017.2363.
9.Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way. Huang S*,Xu W, Su B, Luo L.Bioessays. 2014,36(3):293-304.
10.Spatial and Temporal Distribution of Dopaminergic Neurons during Development in Zebrafish.Du Y, Guo Q, Shan M, Wu Y,Huang S,Zhao H, Hong H, Yang M, Yang X, Ren L, Peng J, Sun J, Zhou H, Li S, Su B. Front Neuroanat.2016 Nov 28;10:115. doi: 10.3389/fnana.2016.00115.
11.The role of histone ubiquitination during spermatogenesis.Sheng K, Liang X,Huang S,Xu W.Biomed Res Int.2014;2014:870695. doi: 10.1155/2014/870695
12.Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish. Huang S,Ma J, Liu X, Zhang Y, Luo L. J Biol Chem. 2011,12;286(32):28533-43. doi: 10.1074/jbc.M111.244327.
13.NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.Liu X,Huang S,Ma J, Li C, Zhang Y, Luo L.J Cell Biol.2009,23;184(6):805-15. doi: 10.1083/jcb.200806074.
14.Geminin is required for left-right patterning through regulating Kupffer's vesicle formation and ciliogenesis in zebrafish.Huang S,Ma J, Liu X, Zhang Y, Luo L.Biochem Biophys Res Commun. 2011,410(2):164-9. doi: 10.1016/j.bbrc.2011.04.085.