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科研成果

发布日期:2024-09-19    作者:     来源:    点击:

 


  • 科研项目

    5年以来,学院共获得各类科研项目资助161项,其中国家自然科学基金14项,科技部子课题1项,省部级研究课题23项,厅局级及其他科研项目99项,横向研究项目13项,社科项目11项,科研经费2112.68万元。近五年在国内外期刊上发表科研论文333篇(一作或通讯作者),其中111篇学术论文被SCI收录,最高IF 29分(Cell Metabolism,2023)。6篇论文连续三年入选ESI高被引论文。1篇论文入选《高质量科技期刊分级目录》。

    附表1部分国家级及省部级项目

年度

负责人

项目名称

项目来源

项目类别

2022

苏炳银

科技创新2030-脑科学重大项目“人脑组织资源库及地区脑库协作网络平台”子课题

国家科技部

子课题

2024

董勇

ELK1通过抑制中性粒谱系分化促进急性髓系白血病发病进程的机制研究

国家自然科学基金

面上项目

2024

王瑾瑄

反式烯酰-CoA还原酶Tecr抑制mTORC1活性维持血脑屏障功能的机制研究

国家自然科学基金

青年项目

2023

张小庆

NF-kB p65促进CEP192与Aurora A结合进而调控中心体成熟的作用机制研究

国家自然科学基金

青年基金

2023

黄继昌

血红素关键合成酶ALAD在扩张型心肌病发病中的机制研究

国家自然科学基金

青年基金

2022

谭泓琳

LanCL1在调节多巴胺能神经元存活中的作用与机制研究

国家自然科学基金

青年基金

2022

韩蓉

AAAP-like蛋白介导羊无浆体入侵宿主细胞的机制研究

国家自然科学基金

青年基金

2022

董勇

转录因子ELK1在人类中性粒细胞谱系决定过程中的分子机制研究

国家自然科学基金

青年基金

2021

贾旭

RNA感应元件armZL调控细菌耐药基因表达研究

国家自然科学基金

面上项目

2021

罗蓉

CACNA1B基因点突变导致房室结折返性心动过速的作用机制研究

国家自然科学基金

面上项目

2021

胥建辉

臂旁外侧核强啡肽原神经元在LPS诱导发热中的作用及其机制研究

国家自然科学基金

青年基金

2020

黄四洲

dnase1l1在器官左右不对称模式建成中的作用及机制研究

国家自然科学基金

面上项目

2020

李顺

自噬基因UVRAG协同ITCH促进Notch1内体-溶酶体途径降解抑制黑色素瘤恶性增殖研究

国家自然科学基金

青年基金

2019

刘畅

精氨酸酶II对糖尿病视网膜小胶质细胞活化的调控机制研究

国家自然科学基金

青年基金

2019

梁芸丹

长链非编码RNA NONHSAT102891启动子区遗传变异与抑郁症发病的关系及功能研究

国家自然科学基金

青年基金

2024

罗蓉

基于人工智能构建心肌病临床死亡风险预测和猝死预警系统

省科技厅

面上项目

2022

太颢然

p53-HtrA2反馈环路调控帕金森病中多巴胺能神经元细胞命运

省科技厅

自由探索

2022

张小庆

N-亚油酰酪氨酸上调DJ-1激活Nrf2/ARE信号通路保护多巴胺能神经元的作用及机制研究

省科技厅

自由探索

2022

李秀

精氨酸酶II对阿尔茨海默氏病星形胶质细胞活化的调控机制研究

省科技厅

自由探索

2022

梁芸丹

GPHN-ATP6V1D在抑郁症中的交互作用及机制研究

省科技厅

自由探索

2022

韩玉萍

miR-7/NDs/RVG29对帕金森病多巴胺能神经元损伤的保护作用及机制研究

省科技厅

自由探索

2022

李顺

力信号介导TRPV4-p38/JNK-ZKSCAN3通路靶向TGF-β自噬降解促进椎 间盘退变的机制研究

省科技厅

面上项目

2022

张先琴

lncRNA TRPM2-AS-STAT3信号轴抑制胃癌细胞凋亡的分子机制研究

省科技厅

面上项目

2022

谭泓琳

LanCL1激活AKT活性的分子机制研究

省科技厅

面上项目

2022

韩云蕾

阴沟肠杆菌CRISPR/Cas9基因组编辑技术的建立与评价

省科技厅

面上项目

2022

聂鑫

类球红细菌代谢物促进腊肠酯类风味物质形成的机理研究

省科技厅

面上项目

2022

杨平

溶瘤病毒oHSV-1介导三联miRNA表达及其抗口腔鳞癌机制研究

省科技厅

面上项目

2022

罗丹

MALT1介导AKT活化促进结肠癌生长的功能及机制研究

省科技厅

自由探索

2022

陈龙

Bach2自噬调控UVA光老化驱动黑色素瘤相关成纤维细胞促炎表型极化

省科技厅

自由探索

2021

李淑蓉

p150Glued磷酸化修饰在多巴胺神经元轴突逆行运输中的作用及机制研究

省科技厅

应用基础研究

2021

解学敏

BCL11A增强子元件对智能障碍亚型的诊断与分子机制

省科技厅

应用基础研究

2021

刘敏(指导老师黄四洲)

MCM3在斑马鱼T细胞发育及急性T淋巴细胞性白血病(T-ALL)发生中的作用及机制研究

省科技厅

苗子工程重点项目

2021

黄四洲

cdon在斑马鱼KV/cilia发育及器官左右不对称模式建成中的作用机制研究

省科技厅

中央引导地方专项

2020

黄四洲

RA信号与其靶标基因Cxcr4a在心脏细胞命运决定、细胞迁移及后期形态建成中的作用机制及关联性研究

省科技厅

应用基础研究

2020

杨平

新型溶瘤病毒oHSV 1-TRAIL抗口腔鳞癌溶瘤效应及机制研究

省科技厅

重点研发项目

2020

罗蓉

基于药物基因组学的扩张性心肌病精准医疗

省科技厅

重点研发项目

2020

苏炳银

发育与再生四川省重点实验室

省科技厅

省重点实验室补助

2019

苏炳银

小脑浦肯野细胞在帕金森病发生中的作用及机制(省重)

省科技厅

应用基础研究

 

附表2 代表性学术论文

作者

题目

刊物/论文集名称

IF

发表年度

唐瑜

Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4

Cell Metabolism

29

2023

罗丹

PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

Cell Reports Medicine

16.988

2022

王辉

The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors

NATURE COMMUNICATIONS

16.6

2022

张洁

Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

Neuron

16.2

2023

李顺

The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis

Autophagy

14.6

2024

李顺

SARS-CoV-2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

Journal of Medical Virology

12.17

2023

罗丹

Antioxidant neoagarooligosaccharides (NAOs) and dietary fiber production from red algae Gracilariopsis lemaneiformis using enzyme assisted one-step process

Food Hydrocolloids

11.504

2022

贾旭

Different countries need strengthen water management to improve human health

JOURNAL OF CLEANER PRODUCTION

11.1

2022

董勇

Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model

Redox biology

10.787

2022

贾旭

Promising natural products against SARS-CoV-2 Structure, function, and clinical trials.

PHYTOTHERAPY RESEARCH

9.388

2022

周健康

CircPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription

Cellular and Molecular Life Sciences

9.207

2023

贾旭

A pyrF-Based Efficient Genetic Manipulation Platform in Acinetobacter baumannii To Explore the Vital DNA Components of Adaptive Immunity for I-F CRISPR-Cas

MICROBIOLOGY SPECTRUM

9.043

2022

罗丹

Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer

Oncogene

8.756

2022

黄四洲

Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking

plos biology

8.386

2019

罗丹

Antimicrobial high molecular weight pectin polysaccharides production from diverse citrus peels using a novel PL10 family pectate lyase

International Journal of Biological Macromolecules

8.025

2023

罗蓉

Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole-exome sequencing.

Experimental Cell Research

7.919

2020

贾旭

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

Cytokine Growth Factor Rev

7.638

2020

张绍兰

Global genome and comparative transcriptomic analysis reveal the inulin consumption strategy of Lactiplantibacillus plantarum QS7T

FOOD RESEARCH INTERNATIONAL

7.425

2022

黄继昌

Integrative analysis of multiomics data identifies selenium-related gene ALAD associating with keshan disease

FREE RADICAL BIOLOGY AND MEDICINE

7.4

2022

董勇

Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation

Stem Cell Res. Ther.

7.1

2024

张录顺

Accuracy of quantitative diffusion-weighted imaging for differentiating benign and malignant pancreatic lesions: a systematic review and meta-analysis

European Radiology

7.034

2021

王瑾萱

Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis

Genes Dis

6.9

2024

张洁

Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats

Acta Pharmacol Sin

6.9

2024

张录顺

The effectiveness of distraction as preoperative anxiety management technique in pediatric patients_ A systematic review and meta-analysis of randomized controlled trials

International Journal of Nursing Studies

6.612

2022

刘畅

A Mitophagy-Related Gene Signature for Subtype Identification and Prognosis Prediction of Hepatocellular Carcinoma

International Journal of Molecular Sciences

6.208

2022

贾旭

Predictions of thermodynamic properties for hydrogen sulfide

Journal of Molecular Liquids

6.165

2020

梁媛媛

MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy

Biomedicines

6.081

2021

张晓

Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamics

Frontiers in Cellular and Infection Microbiology

6.073

2022

李顺

Coronavirus usurps the autophagy-lysosome pathway and induces membranes rearrangement for infection and pathogenesis

Frontiers in Microbiology

6.064

2022

黄四洲

Mcm5 Represses Endodermal Migration through Cxcr4a-itgb1b Cascade Instead of Cell Cycle Control

Biomolecules

6.064

2022

张晓

Mechanism of N-0385 blocking SARS-CoV-2 to treat COVID-19 based on molecular docking and molecular dynamics

Frontiers in Microbiology

6.064

2022

黄继昌

One-day thermal regime extends the lifespan in Caenorhabditis elegans

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

6

2022

张晓

Exploring the mechanism of action of licorice in the treatment of COVID-19 through bioinformatics analysis and molecular dynamics simulation

Frontiers in Pharmacology

5.988

2022

黄四洲

Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells

Frontiers in Pharmacology

5.988

2023

刘飘洋

Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases

International Journal of Molecular Sciences

5.924

2021

徐锡超

Substrate Stiffness Drives Epithelial to Mesenchymal Transition and Proliferation through the NEAT1-Wnt/β-Catenin Pathway in Liver Cancer

International Journal of Molecular Sciences

5.924

2021

黄继昌

Integrative Analyses Identify Potential Key Genes and Calcium-Signaling Pathway in Familial Atrioventricular Nodal Reentrant Tachycardia Using Whole-Exome Sequencing

Frontiers in Cardiovascular Medicine

5.846

2022

张录顺

Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review

Front. Immunol.

5.7

2024

郑人源

Molecular mechanisms of Huanglian Jiedu decoction in treating Alzheimer’s disease by regulating microbiome via network pharmacology and molecular docking analysis

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

5.7

2023

贾旭

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene

frontiers in microbiology

5.640

2021

贾旭

The PER3(rs772027021) SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria

Journal of Molecular Medicine

5.606

2023

黄四洲

Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish

Front Cell Dev Biol

5.5

2022

张全

Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect

Pharmaceutics

5.4

2023

梁芸丹

N6-methyladenosine RNA modification: A promising regulator in central  nervous system injury

Experimental Neurology

5.33

2021

陈龙

Has-miR-300-GADD45B promotes melanoma growth via cell cycle

AGING-US

5.2

2023

邓珊珊

Lactic acid bacteria with a strong antioxidant function isolated from "Jiangshui," pickles, and feces

Front Microbiol

5.2

2023

贾旭

Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Frontiers in Microbiology

5.2

2023

陈恬

Hypericin Blocks the Function of HSV-1 UL12 and Suppresses Viral Replication

Journal of Ethnopharmacology

5.195

2022

罗丹

p53 mediated G1 arrest requires the induction of both p21 and Killin in human colon cancer cells

Cell cycle

5.173

2022

贾旭

Coexistence of tet(A) and blaKPC-2 in the ST11 hypervirulent tigecycline- and carbapenem-resistant Klebsiella pneumoniae isolated from a blood sample

European Journal of Clinical Microbiology & Infectious Diseases

5.103

2023

太颢然

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

Frontiers in Immunology

5.085

2020

单娟

T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus

Frontiers in Immunology

5.085

2020

李顺

Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines

Journal of Physiology and Biochemistry

5.08

2022

贾旭

Shedding of SARS-CoV-2 for 85 Days in COVID-19 Patients With Type 2 Diabetes Mellitus and Lung Metastasis: A Case Report.

FRONTIERS IN MEDICINE

5.058

2022

谭泓琳

Significant metabolic alterations in patients with hepatitis B virus replication observed via serum untargeted metabolomics shed new light on hepatitis B virus infection.

Journal of Drug Targeting

5.016

2022

贾旭

A promising nucleic acid therapy drug: DNAzymes and its delivery system

Frontiers in Molecular Biosciences

5

2023

曹慧

生物信息数据库分析 INHBA在结直肠癌中的表达及临床意义

电子科技大学学报


2022

单娟

Rapamycin facilitates differentiation of regulatory T cells via enhancement of oxidative phosphorylation

Cellular Immunology

4.868

2021

李顺

The Double-Edged Effects of MLN4924: Rethinking Anti-Cancer Drugs Targeting the Neddylation Pathway

Biomolecules

4.8

2024

谭泓琳

Lipid metabolism characterization in gastric cancer identifies signatures to predict prognostic and therapeutic responses

Frontiers in Genetics

4.772

2022

贾旭

Potential Treatment of Chinese and Western Medicine Targeting Nsp14 of SARS-CoV-2

J Pharm Anal

4.769

2021

张晓

Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics

Frontiers in Physiology

4.755

2022

曹康

The therapeutic potential of attenuated diphtheria toxin delivered by an adenovirus vector with survivin promoter on human lung cancer cells

Cancer Biology & Therapy

4.742

2021

贾旭

Editorial: Interrelationships between human microbiology and health of the elderly

Front. Cell. Infect. Microbiol.

4.6

2024

杨平

MAPK Cascade Signaling Is Involved in alpha-MMC Induced Growth Inhibition of Multiple Myeloma MM.1S Cells via G2 Arrest and Mitochondrial-Pathway-Dependent Apoptosis In Vitro

PHARMACEUTICALS

4.6

2023

梁芸丹

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

BMC Psychiatry

4.4

2023

李淑蓉

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

Front Pharmacol

4.4

2024

张晓

Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments

Neurochem. Int.

4.4

2024

梁芸丹

Haplotype analysis of long-chain non-coding RNA NONHSAT102891
promoter polymorphisms and depression in Chinese individuals: A
case-control association study

WORLD JOURNAL OF PSYCHIATRY

4.2

2023

杨平亮

A Meta-Analysisof 5-HydroxytryptamineReceptor1B PolymorphismsWithRiskofMajor DepressiveDisorderandSuicidal Behavior

frontiers in Psychiatry

4.157

2021

张录顺

A bibliometric and visual analysis of epigenetic research publications for Alzheimer's disease (2013-2023)

Front. Aging Neurosci.

4.1

2024

张洁

The Role of Prostaglandin E2?Synthesized in Rat Lateral Parabrachial Nucleus in LPS-Induced Fever

Neuroendocrinology

4.1

2022

张录顺

Transarterial Chemoembolization Plus Sorafenib versus Transarterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma: An Umbrella Review of Meta-Analyses and Systematic Reviews

Journal of Hepatocellular Carcinoma

4.1

2023

贾旭

Co-occurrence of 3 different plasmids in an extensively drug-resistant hypervirulent Klebsiella pneumoniae isolate causing urinary tract infections.

J Glob Antimicrob Resist

4.035

2020

张先琴

Inhibition of gastric cancer cell apoptosis by long noncoding RNA TRPM2-AS via mitogen-activated protein kinase and activators of transduction-3

journal of gastroenterology and hepatology

4.029

2021

贾旭

Synergistic Effects from Combination of Cryptotanshinone and Fosfomycin Against Fosfomycin-Susceptible and Fosfomycin-Resistant Staphylococcus aureus.

Infect Drug Resist

4.003

2020

潘渠

The dyeing effect of acridine orange for multiple plasmid systems is sensitive to temperature

JOURNAL OF CELLULAR BIOCHEMISTRY

4

2023

聂政

The Role of BDNF on Neural Plasticity in Depression

Frontiers in cellular neuroscience.

3.921

2020

姜玉峰

Dihydroartemisinin induces ER stress-dependent apoptosis of Echinococcus protoscoleces in vitro

Acta Biochim Biophys Sin

3.848

2020

姜玉峰

The effects of 2-aminoethoxydiphenyl borate and dantrolene on rat bones treated with NaAsO2

Acta Biochim Biophys Sin

3.848

2021

杨拯

Validity and reliability of the sleep health index among patients with spinal degenerative diseases

Sleep Med.

3.8

2024

潘渠

Whole genome sequence analysis of two subspecies of Companilactobacillus Futsaii and experimental verification of drug resistance and effect on the exploratory behavior of mice based on unique gene

PLOS ONE

3.752

2022

邓峰美

Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis

Experimental Cell Research

3.7

2023

邓峰美

Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis

Experimental Cell Research

3.7

2023

贾旭

Potential Genes Associated with COVID-19 and Comorbidity

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

3.642

2022

贾旭

Carriage of Distinct mcr-1-Harboring Plasmids by Unusual Serotypes of Salmonella

Adv Biosyst.

3.536

2020

潘渠

Multiplasmid DNA in agarose gel electrophoresis: Suitable dye and temperature is essential for prominent profiles

Electrophoresis

3.535

2021

伍丽娜

Disulfide Cross-Linked Poly(Methacrylic Acid) Iron Oxide Nanoparticles for Efficiently Selective Adsorption of Pb(II) from Aqueous Solutions

ACS Omega

3.512

2020

黄敏

A systematic review and meta-analysis comparing the diagnostic capability of automated breast ultrasound and contrast-enhanced ultrasound in breast cancer

Front. Oncol.

3.5

2024

张录顺

Recent status and trends of nanotechnology in cervical cancer: a systematic review and bibliometric analysis

Front. Oncol.

3.5

2024

梁芸丹

Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases_ A Systematic Review and Meta-Analysis

Disease Markers

3.464

2022

张录顺

Transjugular intrahepatic portosystemic shunt for portal vein cavernous transformation: a systematic review and single-arm meta-analysis

Digestive Diseases

3.421

2022

张录顺

Causal Association Between Allergic Diseases and Dementia: Evidence from Multivariate Mendelian Randomization Study

J Alzheimers Dis

3.4

2024

邓峰美

Exploring the interplay between methylation patterns and non-coding RNAs in non-small cell lung cancer: Implications for pathogenesis and therapeutic targets

Heliyon

3.4

2024

张录顺

Global research trends on the links between NfL and neurological disorders: A bibliometric analysis and review

Heliyon

3.4

2024

邓峰美

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Heliyon

3.4

2024

苏炳银

Curcumin inhibits propofol-induced autophagy of MN9D cells via Akt/mTOR/p70S6K signaling pathway

Cell Biol. Int.

3.3

2024

莫春芬

Drug Resistance in Hepatocellular Carcinoma: Theoretical Basis and Therapeutic Aspects

Front. Biosci.

3.3

2024

单娟

TGF-β1 maintains Foxp3 expression and inhibits glycolysis in natural regulatory T cells via PP2A-mediated suppression of mTOR signaling

Immunology Letters

3.276

2020

贾旭

Predcting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontier in genetics

3.26

2020

聂鑫

Interplay between formation of photosynthetic complexes and expression of genes for iron–sulfur cluster assembly in Rhodobacter sphaeroides?

Photosynthesis Research

3.216

2020

杨拯

Association between quality of discharge teaching and self-management in patients after percutaneous coronary intervention: A chain mediation model

J. Clin. Nurs.

3.2

2024

梁芸丹

Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population

Neuropsychiatric Disease and Treatment

3.2

2023

贾旭

The function of small RNA in Pseudomonas aeruginosa.

PEERJ

3.061

2022

刘巧凤

Minocycline alleviates the symptoms of morphine withdrawal via the CaMKII-Ras-ERK signaling pathway

NEUROSCIENCE LETTERS

3.046

2021

黄敏

Construction and validation of a method for automated time label segmentation of heart sounds

Front Artif Intell

3

2024