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科研团队

发布日期:2024-09-19    作者:     来源:    点击:


  • 病原微生物学研究团队

    病原生物学研究团队拥有教师14人,含博士8人。近5年来,共获批科研项目28项,经费318万元,含国家自然科学基金4项,省部级项目2项。主要的研究方向有肿瘤的病毒载体基因治疗,抗病毒药物(天然药物)的研究,人体寄生虫的防治和治疗。

    部分代表性论文如下:

作者

题目

刊物/论文集名称

影响因子

贾旭

Different countries need strengthen water management to improve human health

JOURNAL OF CLEANER PRODUCTION

11.10

贾旭

Promising natural products against SARS-CoV-2 Structure, function, and clinical trials.

PHYTOTHERAPY RESEARCH

9.39

贾旭

A pyrF-Based Efficient Genetic Manipulation Platform in Acinetobacter baumannii To Explore the Vital DNA Components of Adaptive Immunity for I-F CRISPR-Cas

MICROBIOLOGY SPECTRUM

9.04

贾旭

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

Cytokine Growth Factor Rev

7.64

王瑾萱

Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis

Genes Dis

6.90

贾旭

Predictions of thermodynamic properties for hydrogen sulfide

Journal of Molecular Liquids

6.17

贾旭

Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes.

Neuropsychiatric Disease and Treatment

5.882

贾旭

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene

frontiers in microbiology

5.64

贾旭

The PER3(rs772027021) SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria

Journal of Molecular Medicine

5.61

贾旭

Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Frontiers in Microbiology

5.20

陈恬

Hypericin Blocks the Function of HSV-1 UL12 and Suppresses Viral Replication

Journal of Ethnopharmacology

5.20

贾旭

Coexistence of tet(A) and blaKPC-2 in the ST11 hypervirulent tigecycline- and carbapenem-resistant Klebsiella pneumoniae isolated from a blood sample

European Journal of Clinical Microbiology & Infectious Diseases

5.10

贾旭

Shedding of SARS-CoV-2 for 85 Days in COVID-19 Patients With Type 2 Diabetes Mellitus and Lung Metastasis: A Case Report.

FRONTIERS IN MEDICINE

5.06

贾旭

A promising nucleic acid therapy drug: DNAzymes and its delivery system

Frontiers in Molecular Biosciences

5.00

贾旭

Potential Treatment of Chinese and Western Medicine Targeting Nsp14 of SARS-CoV-2

J Pharm Anal

4.77

曹康

The therapeutic potential of attenuated diphtheria toxin delivered by an adenovirus vector with survivin promoter on human lung cancer cells

Cancer Biology & Therapy

4.74

贾旭

Editorial: Interrelationships between human microbiology and health of the elderly

Front. Cell. Infect. Microbiol.

4.60

贾旭

Co-occurrence of 3 different plasmids in an extensively drug-resistant hypervirulent Klebsiella pneumoniae isolate causing urinary tract infections.

J Glob Antimicrob Resist

4.04

贾旭

Synergistic Effects from Combination of Cryptotanshinone and Fosfomycin Against Fosfomycin-Susceptible and Fosfomycin-Resistant Staphylococcus aureus.

Infect Drug Resist

4.00

潘渠

The dyeing effect of acridine orange for multiple plasmid systems is sensitive to temperature

JOURNAL OF CELLULAR BIOCHEMISTRY

4.00

潘渠

Whole genome sequence analysis of two subspecies of Companilactobacillus Futsaii and experimental verification of drug resistance and effect on the exploratory behavior of mice based on unique gene

PLOS ONE

3.75

贾旭

Potential Genes Associated with COVID-19 and Comorbidity

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

3.64

贾旭

Carriage of Distinct mcr-1-Harboring Plasmids by Unusual Serotypes of Salmonella

Adv Biosyst.

3.536

潘渠

Multiplasmid DNA in agarose gel electrophoresis: Suitable dye and temperature is essential for prominent profiles

Electrophoresis

3.54

贾旭

Predcting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontier in genetics

3.26

韩蓉

Molecular detection of Anaplasma infections in ixodid ticks from the Qinghai-Tibet Plateau

Infection Disease Poverty

3.067

贾旭

The function of small RNA in Pseudomonas aeruginosa.

PEERJ

3.06

潘渠

A pretreatment scheme for plasmid extraction contained sugar, high concentration lysozyme and mild lysozyme removal

Analytical Biochemistry

2.90

王瑾瑄

Biomechanics-mediated endocytosis in atherosclerosis

Front Cardiovasc Med

2.80

陈恬

Synthesis, biological activities, and docking study of novel chalcone-pleuromutilin derivatives

Chemical Biology & drug

2.55

贾旭

Influenza-like illnesses caused by a cluster of imported Italian COVID-19.

J Med Virol

2.327

贾旭

The development and application of pseudoviruses: assessment of SARS-CoV-2 pseudoviruses

PEERJ

2.30

贾旭

Comparison of the effectiveness and safety of insulin and oral hypoglycemic drugs in the treatment of gestational diabetes mellitus: a meta-analysis of 26 randomized controlled trials

GYNECOLOGICAL ENDOCRINOLOGY

2.28

贾旭

SARS-CoV-2 and SARS-CoV: Virtual screening of potential inhibitors targeting RNA-dependent RNA polymerase activity (NSP12)

JOURNAL OF MEDICAL VIROLOGY

2.08

 

  • 疫学研究团队

    免疫学研究团队拥有研究人员10人,10人具有博士学历。近5年来,共获批科研项目17项,经费286万元,含国家自然科学基金5项,省部级项目4项。发表学术论文20篇。其中5篇论文影响因子大于10。

    主要研究方向有:

    1.Teff/Treg平衡调控的作用及代谢信号机制

    2.Killin在肿瘤中的生物学功能

    3.细胞自噬在黑色素瘤发生发展中的作用与机制

    4.造血发育与免疫细胞再生

    5.多组学分析中药分子抗肿瘤机制

    部分代表性论文如下:

作者 题目 刊物/论文集名称 影响因子
罗丹 PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer Cell Reports Medicine 16.988
李顺 The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis Autophagy 14.60
李顺 SARS-CoV-2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis Journal of Medical Virology 12.17
罗丹 Antioxidant neoagarooligosaccharides (NAOs) and dietary fiber production from red algae Gracilariopsis lemaneiformis using enzyme assisted one-step process Food Hydrocolloids 11.50
董勇 Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model Redox biology 10.79
罗丹 Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer Oncogene 8.76
罗丹 Antimicrobial high molecular weight pectin polysaccharides production from diverse citrus peels using a novel PL10 family pectate lyase International Journal of Biological Macromolecules 8.03
董勇 Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation Stem Cell Res. Ther. 7.10
李顺 The potentiality of bacteria todrive SARS-CoV-2 mutation mBio 6.30
李顺 Coronavirus usurps the autophagy-lysosome pathway and induces membranes rearrangement for infection and pathogenesis Frontiers in Microbiology 6.06
陈龙 Has-miR-300-GADD45B promotes melanoma growth via cell cycle AGING-US 5.20
罗丹 p53 mediated G1 arrest requires the induction of both p21 and Killin in human colon cancer cells Cell cycle 5.17
单娟 T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus Frontiers in Immunology 5.09
李顺 Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines Journal of Physiology and Biochemistry 5.08
单娟 Rapamycin facilitates differentiation of regulatory T cells via enhancement of oxidative phosphorylation Cellular Immunology 4.87
李顺 The Double-Edged Effects of MLN4924: Rethinking Anti-Cancer Drugs Targeting the Neddylation Pathway Biomolecules 4.80
张先琴 Inhibition of gastric cancer cell apoptosis by long noncoding RNA TRPM2-AS via mitogen-activated protein kinase and activators of transduction-3 journal of gastroenterology and hepatology 4.03
单娟 TGF-β1 maintains Foxp3 expression and inhibits glycolysis in natural regulatory T cells via PP2A-mediated suppression of mTOR signaling Immunology Letters 3.28
陈龙 The PDZ domain of the E protein in SARS-CoV induces carcinogenesis and poor prognosis in LUAD Microbes Infect 2.60
徐艳 Risk factors for nonunion of osteoporotic vertebral compression fracture: a case‒control study BMC Musculoskelet Disord 2.20
陈龙 A prognostic model based on the COL1A1-network in gastric cancer American Journal of Translational Research 2.20
陈龙 Multicellular network analysis of melanoma heterogeneity by scRNA-seq American Journal of Translational Research 2.20
单娟 Rapamycin Modulate Treg/Th17 Balance via Regulating Metabolic Pathways: A Study in Mice Transplantation Proceedings 0.78
徐艳 地塞米松联合雌激素干预脊髓钝挫伤大鼠白细胞介素6、Caspase3和Bcl-2的表达 中国组织工程研究
徐艳 游泳运动对木瓜蛋白酶诱导大鼠膝关节骨性关节炎的预防作用研究 现代中西医结合杂志
罗丹 肠缺血再灌注损伤相关分子机制的研究进展 西南国防医药

 

  • 发育与再生研究团队

    实验室以成都医学院人体解剖与组织胚胎学、病理学教研室为牵头单位和组成核心,近年实验室为建设博士学位授权学科点和四川省重点实验室优秀人才梯队,下大力从上海交通大学、中国医学科学院北京协和医学院、浙江大学、四川大学等国内著名学府引进多名年龄结构合理、专业方向与本学科实验室密切结合的高水平博士,组成学缘关系广泛、专业互补、研究方向集中的学科和实验室人才梯队。实验室现有教授8人、副教授(副研究员)15人、高级实验师2人、博士生导师2人,其中,博士28人、硕士19人。近5年承担国家级课题20余项,省部级课题近30项,其他课题60余项,共发表SCI收录的国际主流学术期刊论文60余篇,获得省部级科学技术进步二、三等奖共3项,出版专著及教材共8部,主办或承办大型国内专业学术会议共2次。实验室建筑面积1200平方米,其他基地面积6000多平方米,拥有激光共聚焦扫描显微镜、活细胞工作站和斑马鱼系统等实验仪器设备约190台,价值1800余万元。实验室与美国哈佛大学等国内外知名大学和科研机构建立了良好的合作关系。

  • 体温与炎症研究团队

    https://twyz.cmc.edu.cn/

  • 病理学研究团队

    病理学研究团队拥有研究人员15人,其中10人具有博士学历。近5年来,共获批科研项目34项,经费438万元,获批国家自然科学基金3项,省部级项目4项。

    主要研究方向:

  1. 肿瘤的发病机制和干预策略

  2. 呼吸系统肿瘤基础与临床

  3. 肿瘤病理与分子病理

  4. 阿片类药物的成瘾和复吸研究

  5. 肝纤维化干细胞免疫治疗研究

     

    部分代表性论文如下:

作者

题目

刊物/论文集名称

影响因子

周健康

CircPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription

Cellular and Molecular Life Sciences

9.207

张绍兰

Global genome and comparative transcriptomic analysis reveal the inulin consumption strategy of Lactiplantibacillus plantarum QS7T

FOOD RESEARCH INTERNATIONAL

7.425

张录顺

Accuracy of quantitative diffusion-weighted imaging for differentiating benign and malignant pancreatic lesions: a systematic review and meta-analysis

European Radiology

7.034

张录顺

The effectiveness of distraction as preoperative anxiety management technique in pediatric patients_ A systematic review and meta-analysis of randomized controlled trials

International Journal of Nursing Studies

6.612

张录顺

Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review

Front. Immunol.

5.7

杨平

MAPK Cascade Signaling Is Involved in alpha-MMC Induced Growth Inhibition of Multiple Myeloma MM.1S Cells via G2 Arrest and Mitochondrial-Pathway-Dependent Apoptosis In Vitro

PHARMACEUTICALS

4.6

孙静

Autophagy Inhibition via Downregulation of Becn1 Improves the Antifibrotic Potential of Mesenchymal Stem Cells in Experimental Liver Fibrosis

The Journal of Cellular Physiology

4.522

李淑蓉

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

Front Pharmacol

4.4

张录顺

A bibliometric and visual analysis of epigenetic research publications for Alzheimer's disease (2013-2023)

Front. Aging Neurosci.

4.1

张录顺

Transarterial Chemoembolization Plus Sorafenib versus Transarterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma: An Umbrella Review of Meta-Analyses and Systematic Reviews

Journal of Hepatocellular Carcinoma

4.1

邓峰美

Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis

Experimental Cell Research

3.7

邓峰美

Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis

Experimental Cell Research

3.7

张录顺

Recent status and trends of nanotechnology in cervical cancer: a systematic review and bibliometric analysis

Front. Oncol.

3.5

张录顺

Transjugular intrahepatic portosystemic shunt for portal vein cavernous transformation: a systematic review and single-arm meta-analysis

Digestive Diseases

3.421

张录顺

Causal Association Between Allergic Diseases and Dementia: Evidence from Multivariate Mendelian Randomization Study

J Alzheimers Dis

3.4

邓峰美

Exploring the interplay between methylation patterns and non-coding RNAs in non-small cell lung cancer: Implications for pathogenesis and therapeutic targets

Heliyon

3.4

张录顺

Global research trends on the links between NfL and neurological disorders: A bibliometric analysis and review

Heliyon

3.4

邓峰美

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Heliyon

3.4

邓峰美

Pax6 contributes to the activation and proliferation of hepatic stellate cells via activating hedgehog/gli1 pathway.

Biochemical and Biophysical Research Communications

2.985

张录顺

Global Research Trends and Hotspots for Ferroptosis, Necroptosis, and Pyroptosis in Alzheimer's Disease from the Past to 2023: A Combined Bibliometric Review

J Alzheimers Dis Rep

2.8

张录顺

The effectiveness of problem-based learning and case-based learning teaching methods in clinical practical teaching in TACE treatment for hepatocellular carcinoma in China: a bayesian network meta-analysis

BMC Med. Educ.

2.7

李淑蓉

Primary hyaline vascular Castleman disease of the kidney: case report and literature review

diagnostic pathology

2.53

张录顺

Comprehensive landscape and future perspectives of non-coding RNAs in esophageal squamous cell carcinoma, a bibliometric analysis from 2008 to 2023

Pathol. Oncol. Res.

2.3

李淑蓉

Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms

The Journal of Toxicological Sciences. 2020

1.737

程丽

Uterine artery embolization versus hysterectomy in the treatment of refractory postpartum hemorrhage: a systematic review and metaanalysis

The Journal of Maternal-Fetal & Neonatal Medicine

1.737

程丽

Efficacy and safety of recombinant human interleukin -11 in the treatment of acute leukemia patients with chemotherapy-induced thrombocytopenia: A systematic review and meta-analysis

Journal of Evaluation in Clinical Practice

1.681

张录顺

Clinical outcomes of radiofrequency ablation using a radiofrequency needle device for varicose ulcer: A non-randomized controlled prospective study

Vascular

1.0

张录顺

A Case of Primary Liver Cancer and Hepatic Cystic Echinococcosis

Indian Journal of Surgery

0.437