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姜玉峰 教授

2019-04-18  

姓名:姜玉峰,教授

一、主持或参加科研项目:

1.主持国家自然基金项目《内质网应激在砷致神经细胞毒性中的作用机制及干预研究》(NO. 81360410),2014-2017.

2.主持成都医学院科研基金项目《脱氧胆酸对细粒棘球蚴原头节生长的作用及其机制》,2019-2021

3.参与国家自然基金资助项目《Nrf2-ARE信号通路在细粒棘球蚴中的表达及其作用机制的研究》(NO.u1303121),2014-2017,第二

4.主持兵团博士基金项目《siRNA阻断GRP78表达抑制细粒棘球蚴生长的研究》(NO. 2011BB019),2011-2013.

5主持兵团重点领域科技攻关项目《P38激活剂抑制细粒棘球蚴生长的研究》(NO. 2011BA058),2011-2012.

二、发表期刊论文:

1. Sodium arsenite augments sensitivity of Echinococcus granulosus protoscoleces to albendazole. Exp Parasitol. 2019 Feb 18. (通讯作者,SCI收录,IF:1.623,JCR3区)

2.Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition. Clin Cancer Res. 2018 Sep 4. (第四,SCI收录,IF:10.280,JCR1区)

3.Toxic effects of arsenic trioxide on Echinococcus granulosus protoscoleces through ROS production, and Ca2+-ER stress-dependent apoptosis. Acta Biochim Biophys Sin. 2018 Jun 1;50(6):579-585. (通讯作者,SCI收录,IF:2.200,JCR3区)

4.Effects of trigonelline inhibition of the Nrf2 transcription factor in vitro on Echinococcus granulosus. Acta Biochim Biophys Sin. 2017 Aug 1;49(8):696-70. (通讯作者,SCI收录,IF:2.200,JCR3区)

5. In vitro effect of sodium arsenite on Echinococcus granulosus protoscoleces. Mol Biochem Parasitol. 2016 Jun;207(2):49-55. (通讯作者,SCI收录,IF:2.068,JCR3区)

6. Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus. Exp Parasitol. 2016 Aug;167:76-82. (通讯作者,SCI收录,IF:1.623,JCR3区)

7.Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer. Mol Cancer Ther. 2016 Apr;15(4):593-607. (第四,SCI收录,IF:5.579,JCR2区)

8. Arsenic trioxide negatively affects Echinococcus granulosus. Antimicrob Agents Chemother. 2015 Nov;59(11):6946-51. (通讯作者,SCI收录,IF:4.415,JCR1区)

9. Surgical Treatment of Multiple Hydatid Cysts in the Liver of a Pediatric Patient. Am J Trop Med Hyg, 2015, 92(3): 595-598. (通讯作者,SCI收录,IF:2.699,JCR1区)

10. Subadventitial cystectomy in the management of biliary fistula with liver hydatid disease, Acta Trop, 2015, 141(Pt B): 223-228. (通讯作者,SCI收录,IF:2.270,JCR2区)

11. In vitro and in vivo treatments of Echinococcus granulosus with Huaier aqueous extract and albendazole liposome, Parasitol Res, 2013,112(1): 193-198. (并列第一,SCI收录,IF:2.098,JCR2区)

三、获得专利:

1.姜玉峰,吕海龙,李思源。电穿孔转染干扰RNA到细粒棘球绦虫的方法,2017.05.10,中国,ZL 2014 1 0571966.0

2.吕海龙,姜玉峰,裴学莲。一种用于抑制和治疗细粒棘球蚴病的干扰RNA及其应用,2017.02.15,中国,ZL 2014 1 0571940.6

3.吕海龙,姜玉峰,慕晓玲。 ML3403作为细粒棘球蚴原头节抑制剂的应用,2016.08.24,中国,ZL 2014 1 0571955.2

4.姜玉峰,吕海龙,孙冯。牛磺熊去氧胆酸盐作为活性成分在制备治疗细粒棘球蚴病药物中的应用,2017.09.15,中国,ZL 2014 1 0571963.7

5.吕海龙,姜玉峰,黄珊珊。DRB在制备治疗细粒棘球蚴病药物中的作用,2017.11.14,中国,ZL 2015 1 0447688.2

四、学术奖励:

1. 《PD98059和SB202190在囊型肝包虫手术中局部化疗的应用》,新疆生产建设兵团,兵团科技进步奖三等奖,2014年,排名第1

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